Observational analyses can complement randomized clinical trial findings for the study of HPV vaccine effectiveness

Led by researchers at NDORMS as part of the Data Analysis and Real World Interrogation Network (DARWIN EU) initiative, a new European study has shown that carefully designed observational studies can ...
National Academies of Sciences%2c Engineering%2c and Medicine

Observational Studies in a Learning Health System: Workshop Summary

• The choice between an observational study and a randomized controlled trial (RCT) is not binary. • No algorithm exists for determining whether an observational study or an RCT is best for answering ...
ascopubs.org

Comparison of Population-Based Observational Studies With Randomized Trials in Oncology

Mutational Analysis of Patients With Colorectal Cancer in CALGB/SWOG 80405 Identifies New Roles of Microsatellite Instability and Tumor Mutational Burden for Patient Outcome Comparative efficacy ...
Kaleido Scope

CREST-2 Long-term Observational Extension Study (C2LOE)

CREST-2 (clinicaltrials.gov number: NCT02089217) is a pair of parallel, actively recruiting procedural trials to prevent stroke comparing: 1) carotid endarterectomy (CEA) and intensive medical ...
ascopubs.org

Comparative Effectiveness Research in Oncology Methodology: Observational Data

The goal of comparative effectiveness research is to inform clinical decisions between alternate treatment strategies using data that reflect real patient populations and real-world clinical scenarios ...